α2-Adrenoceptor agonists: shedding light on neuroprotection?
نویسندگان
چکیده
منابع مشابه
Shedding Light on Light*
There are four books describing early studies and views on light, optics and vision that are considered to be landmarks in this branch of science. The first of these is Euclid’s Optica, published about 300BC, in which he postulated that light travelled in straight lines; he described the laws of reflection and described them mathematically. The second is by Ptolemy. He is best known for his 15 ...
متن کاملNon-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection
The amyloid beta (Aβ) pathway is strongly implicated in neurodegenerative conditions such as Alzheimer's disease and more recently, glaucoma. Here, we identify the α2 adrenergic receptor agonists (α2ARA) used to lower intraocular pressure can prevent retinal ganglion cell (RGC) death via the non-amyloidogenic Aβ-pathway. Neuroprotective effects were confirmed in vivo and in vitro in different g...
متن کاملNeuroprotection by dopamine agonists.
Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents. Recent findings of impaired mitochondrial function, altered iron metabolism and increased lipid peroxidation in the substantia nigra of parkinsonian patients emphasize the significance of oxidative stress and free radical formation in the pat...
متن کاملShedding light on NSOM.
I took patience and hard work. Now, finally, researchers are seeing some sunshine break through what was once a cloudy beginning for near-field scanning optical microscopy (NSOM). Paul Barbara of the University of Texas–Austin (UT– Austin) is among a group of analytical chemists who have a deep respect for this tool and see it as a technique ripe with potential, ranging from chemistry to physic...
متن کاملShedding Light on Adaptation
One of the most remarkable features of the vertebrate retina is its ability to adapt to ambient illumination. One can read from this page by candlelight or one can read from it on a sunny afternoon, but the page always appears white and the letters black. It is the molecular trickery of light adaptation that enables photoreceptors to evade saturation and accurately report relative contrast even...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 2005
ISSN: 1471-8391,0007-1420
DOI: 10.1093/bmb/ldh036